ARC Nanotechnology Network
Dr Pawan Sharma

Dr Pawan Sharma

 
Chancelllors Fellow & Research Leader
Faculty of Science
School of Life Sciences
Bldg 4 Level 7 Room 331
15 Broadway Ultimo
NSW 2007
Research Group: University of Technology, Sydney - Protein biochemistry and biophysics
 
Email: link
Phone: 91140331
 
 

Current Research Activities

My lab focuses on discovering and identifying novel mechanisms that may act as first in class targets for treating chronic lung diseases such as asthma and COPD. We utilizes variety of translational model systems involving human airway cells from healthy and patient donors in conjunction with mouse models to test new therapies using variety of novel drug delivery approaches. One such process is autophagy; a highly conserved protective mechanism within the cell, which we have found to be dysregulated or impaired in asthma. We are trying to understand how this fundamental protective mechanism can be exploited to achieve clinical benefit in patients who do not respond to standard therapy while their lungs are constantly remodeled with chronic inflammation. We are also interested in identifying novel and improving existing bronchodilators that target GPCRs to relax the airways. I actively collaborate locally at UTS (SoLS, GSH, CHT), within Australia (Woolcock and Sydney Hospitals) and also with some of the leading Universities in North America.  

Existing Linkages

Woolcock Institute of Medical Research, Sydney, NSW
Thomas Jefferson University, Philadelphia, USA
University of Manitoba, Winnipeg, MB, Canada